Acromegaly results from the hypersecretion of which hormone?

Acromegaly is a disorder characterized by the overgrowth of bones and tissues, most commonly resulting from the hypersecretion of growth hormone. This hypersecretion typically occurs due to a benign tumor on the pituitary gland, known as an adenoma. The excess growth hormone leads to an increase in the levels of insulin-like growth factor 1 (IGF-1), which promotes growth and increase in size of bones and soft tissues.

Growth hormone plays a crucial role in regulating body composition, muscle and bone growth, and metabolism. In individuals with acromegaly, the continuous overproduction of this hormone results in characteristic features such as enlarged hands and feet, facial changes, and other systemic effects.

While cortisol and adrenocorticotropic hormone are associated with other disorders like Cushing's syndrome, and insulin primarily regulates blood glucose levels, it is the growth hormone that is specifically responsible for the symptoms and changes seen in acromegaly. The knowledge of this relationship underscores the importance of identifying and understanding hormonal roles in pathological conditions.