What condition is characterized by a deficiency or hyposecretion of adrenal cortex hormones and includes symptoms like muscle weakness and weight loss?

The condition defined by a deficiency or hyposecretion of adrenal cortex hormones, which includes symptoms such as muscle weakness and weight loss, is Addison’s disease. This disorder arises when the adrenal glands do not produce sufficient amounts of key hormones, particularly cortisol and, in some cases, aldosterone.

Cortisol is essential for regulating metabolism, reducing inflammation, and helping with stress management. When cortisol levels are low due to Addison’s disease, individuals experience fatigue, muscle weakness, and significant weight loss as the body struggles to maintain normal physiological functions.

Additionally, Addison's disease can lead to other symptoms like low blood pressure, hyperpigmentation of the skin, particularly in areas exposed to sunlight, and occasionally, severe cases can result in an adrenal crisis, a life-threatening condition. The underlying causes often include autoimmune reactions, infections, or other diseases impacting the adrenal glands.

Understanding this condition is vital for managing proper treatment plans and recognizing the importance of hormonal balance within the body.