Which of the following is considered an adverse effect of hypersecretion of adrenal hormones?

The correct answer, muscle weakness, is associated with hypersecretion of adrenal hormones, particularly cortisol, which occurs in conditions such as Cushing's syndrome. Elevated levels of cortisol can lead to muscle protein breakdown, resulting in weakness, especially in the proximal muscles. This effect can be linked to the catabolic state induced by excess cortisol, which disrupts normal muscle function and strength.

In contrast, weight loss, increased appetite, and increased energy levels do not typically characterize the hypersecretion of adrenal hormones. For instance, excessive cortisol can often lead to weight gain rather than loss, as it promotes fat accumulation and alters metabolism. Similarly, while energy levels might vary in different contexts, muscle weakness is a more direct and commonly recognized adverse effect of excess adrenal hormones.